Equi-mRNA is a codon-level equivariant language model for mRNA. Synonymous codons are mapped to cyclic subgroups of SO(2), so codon substitutions that preserve amino-acid identity become rotations the model is equivariant to by construction, held in place by an auxiliary equivariance loss and symmetry-aware pooling.
The paper is on arXiv (2508.15103). Architecture, benchmarks against named baselines and the biological interpretability analyses are on the model card.
